In a large bowl, combine the ground beef, bread crumbs, onion, garlic, Bloody Mary mix, ketchup, Worcestershire sauce, oregano, basil, black pepper, cayenne pepper, and salt. Mix until fully combined.
Shape the mixture into a 9x5 inch loaf pan. Bake at 350 degrees F (175 degrees C) for 1 hour, or until the internal temperature reaches 160 degrees F (70 degrees C).
Let the meatloaf cool for 10 minutes before serving.
Interesting Facts
This recipe is a great way to add a zesty twist to a classic comfort food.
The bread crumbs help to keep the meatloaf moist and flavorful.
The cayenne pepper adds a bit of heat to the dish.