In a medium saucepan over medium heat, combine the ketchup, brown sugar, vinegar, bourbon, Worcestershire sauce, mustard, smoked paprika, garlic powder, onion powder, black pepper, and cayenne pepper (if using).
Stir to combine and bring to a simmer, stirring occasionally.
Reduce the heat to low and let the mixture simmer for 10 minutes, stirring occasionally.
Taste and season with salt, if desired.
Remove from the heat and let cool completely before using.
Interesting Facts
Bourbon is a type of whiskey made from corn and other grains, usually aged in charred oak barrels.
Brown sugar is made by adding molasses to white sugar.
Smoked paprika is a type of paprika that has been smoked over a wood fire, giving it a unique smoky flavor.
Worcestershire sauce is a fermented condiment made from anchovies, tamarind, and other ingredients.