Heat olive oil in a large skillet over medium heat. Add onion and garlic; cook, stirring occasionally, until onion is soft and translucent, about 5 minutes.
In a large bowl, combine the ground beef, bread crumbs, eggs, Parmesan cheese, oregano, salt, and pepper. Add the cooked onion and garlic, and mix until well combined.
Form the mixture into a loaf shape and place into a 9x13-inch (23x33-cm) baking dish.
Bake in preheated oven until the loaf is cooked through, about 45 minutes.
Let cool for 10 minutes before slicing and serving.
Interesting Facts
Meatloaf is a popular dish in many countries, including Italy, where it is often referred to as polpettone.
The addition of Parmesan cheese gives this recipe a unique flavor and makes it a great choice for dinner parties.
Leftover meatloaf makes a great sandwich filling or can be used in other recipes such as tacos or casseroles.