In a large bowl, toss cauliflower with oil until evenly coated.
Spread cauliflower onto a baking sheet and bake for 10 minutes.
Meanwhile, in a medium saucepan, heat garlic over medium heat until fragrant, about 1 minute.
Add flour and stir until lightly browned, about 2 minutes.
Slowly whisk in the milk, stirring constantly until thickened, about 5 minutes.
Add onion powder, garlic powder, paprika, thyme, and cheddar cheese. Stir until cheese is melted and sauce is smooth.
Remove cauliflower from oven and pour cheese sauce over top. Sprinkle with panko bread crumbs and return to oven for 10 minutes, or until cheese is bubbly and golden.
Serve hot.
Interesting Facts
Cauliflower is a member of the cruciferous vegetable family, which also includes broccoli, cabbage, and Brussels sprouts.
Cauliflower is a good source of vitamin C, vitamin K, folate, and fiber.
Cauliflower can be cooked in a variety of ways, including roasting, steaming, sautéing, and even raw.