In a large bowl, mix together the ground beef, onion, bell pepper, jalapeno, bread crumbs, cornbread mix, eggs, ketchup, Worcestershire sauce, Italian seasoning, garlic powder, onion powder and black pepper until well combined.
Form the mixture into a loaf shape and place in a baking dish.
Bake in preheated oven for 1 hour and 15 minutes, or until the internal temperature reaches 160°F (70°C).
Let the meatloaf rest for 10 minutes before slicing and serving.
Interesting Facts
Cornbread is a traditional side dish of the American South.
Jalapenos are a type of chili pepper commonly used in Mexican and Tex-Mex cuisine.
Ground beef is a popular choice for meatloaf as it is relatively inexpensive and easy to work with.