In a large bowl, combine the soy sauce, Worcestershire sauce, honey, brown sugar, garlic powder, onion powder, smoked paprika, black pepper, and cayenne pepper and mix together until combined.
Add the thinly sliced beef to the mixture and mix until the beef is completely coated.
Cover the bowl with plastic wrap and place in the refrigerator for at least 4 hours, or overnight.
Preheat the oven to 250 degrees Fahrenheit.
Lay the beef slices on a baking sheet lined with parchment paper.
Bake for 2-3 hours, flipping the slices halfway through to ensure even cooking.
Once the jerky is cooked, remove from the oven and let cool for 5 minutes before serving.
Interesting Facts
Beef jerky has been around for centuries, with some evidence of its consumption dating back to ancient Rome.
It was originally created as a way to preserve meat in the days before refrigeration.
Beef jerky is a great source of protein and is low in fat and calories.