In a bowl, combine the barbecue sauce, Worcestershire sauce, dry rub, beef broth, brown sugar, garlic powder, onion powder, chili powder, and smoked paprika. Mix together until combined.
Place the brisket in a roasting pan, and pour the sauce over the top. Cover the pan with aluminum foil, and bake for 3 to 4 hours, or until the brisket is fork tender.
Once the brisket is cooked, remove it from the oven, and let it rest for 10 minutes before slicing.
Slice the brisket against the grain, and serve with the remaining sauce.
Interesting Facts
Brisket is a cut of beef from the breast or lower chest of the cow.
Barbecue sauce is a popular condiment to serve with brisket.
Brisket is a popular dish to serve for special occasions, like barbecues and picnics.