In a large bowl, mix together the ground beef, breadcrumbs, Parmesan cheese, ketchup, onion, egg, Worcestershire sauce, garlic powder, salt, and pepper.
Form into a loaf shape and place in a 9x5 inch loaf pan.
Bake at 375 degrees F (190 degrees C) for 50 minutes.
Let stand for 10 minutes before slicing.
Interesting Facts
Meatloaf is believed to have originated in Germany in the late 19th century.
The term “meatloaf” was first used in print in the late 1800s.
The classic American version of meatloaf is made with ground beef, bread crumbs, eggs, and seasonings.