In a small bowl, mix together the blackening spice, brown sugar, garlic powder, onion powder, smoked paprika, chili powder, cayenne pepper, cumin, salt, and black pepper.
Rub the mixture into the brisket on all sides.
Heat the olive oil in a large oven-safe skillet or Dutch oven over medium-high heat.
Add the brisket and sear on all sides until browned, about 5 minutes.
Remove the brisket from the skillet and set aside.
In a medium bowl, whisk together the apple cider vinegar, apple juice, Worcestershire sauce, soy sauce, honey, and ketchup.
Pour the mixture over the brisket and cover with foil.
Bake in preheated oven for 2 to 2 1/2 hours, or until the brisket is tender.
Remove from oven and let rest for 10 minutes before slicing.
Interesting Facts
Brisket is a cut of beef from the breast or lower chest of a cow.
Blackening spice is a blend of spices used to season and add flavor to meats.
The longer you cook the brisket, the more tender it will be.
Brisket is best served with a side of mashed potatoes or macaroni and cheese.