In a large skillet over medium heat, cook the ground venison until browned. Add the onion, bell pepper, garlic, oregano, basil, red pepper flakes, salt, and pepper. Cook until vegetables are tender, about 5 minutes.
Stir in the crushed tomatoes and cook for an additional 5 minutes.
Meanwhile, bring a large pot of lightly salted water to a boil. Add spaghetti and cook for 8 to 10 minutes or until al dente; drain.
In a 9x13 inch baking dish, layer the cooked spaghetti, venison mixture, and cheese.
Bake in preheated oven for 30 minutes, or until cheese is melted and bubbly.
Interesting Facts
Venison is a lean, healthy meat that is high in protein and low in fat.
Ground venison can be substituted for ground beef in any recipe.
Baked spaghetti is a classic Italian-American dish.