In a large bowl, combine ground beef, raisins, root beer, breadcrumbs, garlic powder, onion powder, paprika, salt, and pepper. Mix with your hands until combined.
Form the meat mixture into a loaf shape and place in a greased 9x13-inch baking dish.
In a small bowl, mix together ketchup and Worcestershire sauce. Spread the mixture over the top of the meat loaf.
Bake for 35-40 minutes, or until the internal temperature of the meat loaf reaches 160°F.
Let the meat loaf rest for 10 minutes before slicing.
Interesting Facts
Root beer is a carbonated soft drink made from extract of the roots and bark of plants such as sassafras, sarsaparilla, and juniper.
Raisins are dried grapes, and are a great source of vitamins and minerals, fiber, and antioxidants.
The Worcestershire sauce used in this recipe is made with a combination of anchovies, tamarind, and other ingredients.