In a large bowl, combine Brussels sprouts, olive oil, garlic powder, onion powder, paprika, black pepper, and cayenne pepper. Mix until Brussels sprouts are evenly coated.
Spread the Brussels sprouts onto a baking sheet in an even layer. Bake in preheated oven for 20-25 minutes, or until crispy.
Remove Brussels sprouts from oven and transfer to a large bowl. Toss with buffalo sauce until evenly coated.
Taste and season with salt, if desired.
Serve warm.
Interesting Facts
Brussels sprouts are a member of the cabbage family.
Buffalo sauce is made from hot sauce, butter, and vinegar.
Roasting at a high temperature is the best way to achieve crispy Brussels sprouts.