In a large bowl, combine the ground beef, onion, Panko, chile peppers, egg, cumin, chili powder, garlic powder, salt, and black pepper. Mix until everything is evenly combined.
Form the mixture into a loaf shape and place it on a greased baking sheet.
Bake in the preheated oven for 25-30 minutes, or until the internal temperature reaches 165°F.
Allow the meatloaf to cool for 5 minutes before slicing and serving.
Interesting Facts
The green chile peppers add a spicy kick to the meatloaf, but you can use any type of pepper you prefer.
Mexican-style meatloaf is a popular dish in many Southwestern states, particularly New Mexico.
This dish can be served as a main course or as a side dish to tacos, burritos, or other Mexican dishes.