In a large bowl, combine chicken, buffalo sauce, 1 cup of cheese, cream, butter, garlic powder, onion powder, cayenne pepper, salt, and pepper. Stir until combined.
Spread the mixture in an even layer in a greased 9x13 inch baking dish.
Top with the potatoes and remaining cheese.
Bake for 25-30 minutes, or until the potatoes are tender and the cheese is melted and bubbly.
Serve hot.
Interesting Facts
The classic buffalo sauce is made from a mixture of hot sauce, butter, and vinegar.
Cheddar cheese is a popular choice for this dish, but you can also use mozzarella, pepper jack, or even a mix of cheeses.
You can also add other ingredients to the casserole such as cooked bacon, diced bell peppers, or cooked rice.