In a large bowl, combine ground beef, breadcrumbs, egg, ketchup, Worcestershire sauce, onion powder, garlic powder, black pepper, smoked paprika, and oregano.
Mix together until all ingredients are fully incorporated.
Form the mixture into a loaf shape and place in a 9x13 inch baking dish.
Bake for 25-30 minutes, or until cooked through.
Let cool for 10 minutes before slicing and serving.
Interesting Facts
Beef Loaf can be served as a main dish or as a side dish.
Beef Loaf is a great way to use up leftover ground beef.
Beef Loaf can be made ahead of time and frozen for later use.