In a large skillet over medium heat, cook beef, onion, bell pepper, garlic powder, Italian seasoning, salt, and pepper until beef is no longer pink. Drain any excess fat.
Bring a large pot of lightly salted water to a boil. Add macaroni and cook for 8 to 10 minutes or until al dente; drain.
In a 9x13 inch baking dish, combine cooked beef mixture, macaroni, pizza sauce, mozzarella cheese, Parmesan cheese, and pepperoni. Stir to combine.
Bake in preheated oven for 25 minutes, or until cheese is melted and bubbly.
Interesting Facts
Pepperoni is the most popular pizza topping in the United States.
Casseroles are a popular comfort food because they are easy to make and can feed a large group.
This casserole can be prepared in advance and refrigerated for up to 24 hours before baking.